FLIP delta + gamma,凋亡调节蛋白δ+γ抗体

产品编号HZ-6766R
英文名称FLIP delta + gamma
中文名称凋亡调节蛋白δ+γ抗体
别 名CASP8 and FADD like apoptosis regulator; Caspase like apoptosis regulatory protein; Cellular FLICE like inhibitory protein; CFLAR; FLAME 1; FLAME 1 delta; FLICE; Usurpin gamma.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细胞凋亡 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
FLIP delta + gamma,凋亡调节蛋白δ+γ抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35 + 25kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FLIP delta + gamma
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FLIP delta + gamma,凋亡调节蛋白δ+γ抗体PubMedPubMed
产品介绍background:
FLIP (or CASP8 and FADD-like apoptosis regulator) is an apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

Function:
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

Subunit:
TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X.

FLIP delta + gamma,凋亡调节蛋白δ+γ抗体Tissue Specificity:
Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.

Post-translational modifications:
Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.

Similarity:
Belongs to the peptidase C14A family.
Contains 2 DED (death effector) domains.

Gene ID:
8837

Database links:
Entrez Gene: 8837 Human
Entrez Gene: 12633 Mouse
Omim: 603599 Human
SwissProt: O15519-10 Human
SwissProt: O15519-12 Human
SwissProt: O35732 Mouse

FLIP delta + gamma,凋亡调节蛋白δ+γ抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.