F13A1 polyclonal antibody
产品名称： F13A1 polyclonal antibody
英文名称： F13A1 polyclonal antibody
产品编号： PAB7368
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of F13A1.
- Immunogen:
- A synthetic peptide corresponding to amino acids 703-717 of human F13A1.
- Sequence:
- C-HRKLIASMSSDSLRH
- Host:
- Goat
- Theoretical MW (kDa):
- 83.3
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:32000)
Western Blot (0.05-0.2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Clinical significance of measuring blood coagulation factor XIIIA regularly and continuously in patients with Crohn's disease.
Higaki S, Nakano K, Onaka S, Amano A, Tanioka Y, Harada K, Hashimoto S, Sakaida I, Okita K.J Gastroenterol Hepatol. 2006 Sep;21(9):1407-11.
- Entrez GeneID:
- 2162
- Protein Accession#:
- NP_000120.2
- Gene Name:
- F13A1
- Gene Alias:
- F13A
- Gene Description:
- coagulation factor XIII, A1 polypeptide
- Omim ID:
- 134570
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq
- Other Designations:
- FSF, A subunit,TGase,bA525O21.1 (coagulation factor XIII, A1 polypeptide),coagulation factor XIII A1 subunit,coagulation factor XIII, A polypeptide,factor XIIIa,fibrin stabilizing factor, A subunit,fibrinoligase,protein-glutamine gamma-glutamyltransferase
- Interactome
- Gene Pathway
- Related Disease
- Abortion, Habitual
- Abortion, Spontaneous
- Activated Protein C Resistance
- Acute Disease
- Alzheimer Disease
- Alzheimer disease
- Anemia, Sickle Cell
- Anemia, sickle cell
- Aneurysm, Ruptured
- Angina Pectoris
- Antiphospholipid Syndrome
- Arterial Occlusive Diseases
- Arteriosclerosis
- Arthritis, Rheumatoid
- Atherosclerosis
- Atherosclerosis
- Atrial Fibrillation
- beta-Thalassemia
- Blood Coagulation Disorders, Inherited