FITC标记的丝氨酸/苏氨酸蛋白激酶蛋白抗体
产品名称： FITC标记的丝氨酸/苏氨酸蛋白激酶蛋白抗体
英文名称： Anti-Haspin/FITC
产品编号： HZ-15413R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Haspin/FITC Conjugated antibody
FITC标记的丝氨酸/苏氨酸蛋白激酶蛋白抗体
| 英文名称 | Anti-Haspin/FITC |
| 中文名称 | FITC标记的丝氨酸/苏氨酸蛋白激酶蛋白抗体 |
| 别 名 | germ cell associated 2; Germ cell-specific gene 2 protein; GSG2; H-Haspin; Haploid germ cell-specific nuclear protein kinase; HASP_HUMAN; Serine/threonine-protein kinase Haspin. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 染色质和核信号 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 88kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Haspin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Haspins is a protein family containing a distinctive C-terminal kinase domain and a divergent N-terminus. Haspin homologues occur within a diverse group of eukaryotes, including animals, plants and fungi, which suggests an early evolutionary origin. Haspin, a nuclear protein strongly expressed in male germ cells, is responsible for the phosphorylation of histone H3 at Thr-3. Depletion of Haspin RNA prevents normal alignment of chromosomes at metaphase, suggesting a crucial role for haspin during chromosome segregation. Expression of haspin also occurs in adult thymus and bone marrow, with weaker expression in adult prostate, intestine, lung, spleen, and lymph node. The gene encoding human haspin maps to chromosome 17p13. Function: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. Subcellular Location: Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis. Tissue Specificity: Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines. Post-translational modifications: Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis. Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily. Contains 1 protein kinase domain. Database links: UniProtKB/Swiss-Prot: Q8TF76.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
HSPIN是一个含有独特的C-末端激酶结构域和发散的N-末端的蛋白家族。Haspin同源物存在于包括动物、植物和真菌在内的不同真核生物群中，这提示了早期的进化起源。HSPIN是一种在雄性生殖细胞中强表达的核蛋白，负责TH-3组蛋白H3的磷酸化。Haspin RNA的缺失阻止了中期染色体的正常排列，提示haspin在染色体分离过程中起着关键作用。haspin在成人胸腺和骨髓中也有表达，而在成人前列腺、肠、肺、脾和淋巴结中表达较弱。编码人类HSPIN的基因映射到染色体17p13。