MCSF,巨噬细胞克隆刺激因子抗体

产品编号HZ-4910R
英文名称MCSF
中文名称巨噬细胞克隆刺激因子抗体
别 名M-CSF; Macrophage Colony Stimulating Factors; Colony stimulating factor 1 (macrophage); Colony stimulating factor 1; Colony stimulating factor macrophage specific; CSF 1; CSF1; Csfm; Lanimostim; M CSF; Macrophage Colony Stimulating Factor 1; MCSF; MGC31930; CSF1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 发育生物学 信号转导 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
MCSF,巨噬细胞克隆刺激因子抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
细胞定位细胞膜 细胞外基质 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MCSF/M-CSF
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MCSF,巨噬细胞克隆刺激因子抗体PubMedPubMed
产品介绍background:
Four distinct colony-stimulating factors (CSFs) that promote survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte macrophage CSF (GMCSF), granulocyte CSF (GCSF), macrophage CSF (MCSF), and Interleukin-3 (IL-3, Multi CSF). Both GMCSF and IL-3 are multipotential growth factors, stimulating proliferation of progenitor cells from more than one hematopoietic lineage. In contrast, GCSF and MCSF are lineage restricted hematopoietic growth factors, stimulating final mitotic divisions and the terminal cellular maturation of the partially differentiated hematopoietic progenitors.

Function:
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

Subunit:
Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R.

Subcellular Location:
Cell membrane; Single-pass membrane protein. Processed macrophage colony-stimulating factor 1: Secreted, extracellular space.

Post-translational modifications:
N-glycosylated. The predominant soluble form is a chondroitin sulfate-containing proteoglycan.

MCSF,巨噬细胞克隆刺激因子抗体DISEASE:
Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling.

Gene ID:
1435

Database links:
Entrez Gene: 1435 Human
Omim: 120420 Human
SwissProt: P09603 Human
Unigene: 591402 Human

MCSF,巨噬细胞克隆刺激因子抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

-CSF是促使造血细胞分化成粒细胞与巨噬细胞克隆的重要细胞因子,对正常血细胞的形成与造血细胞 的存活、分化、正常造血功能 的维持具有重要作用,直接与间接增加lak细胞的活性,在人体 的细胞因子网络中占有重要 的地位,目前广泛应用于化.放疗 的辅助治疗中。
目前研究主要应用在免疫缺陷性疾病及病毒性疾病：慢性肝病,尤其是与病毒相关的疾病,因其发病过程涉及免疫细胞与造血系统,有可能成为gm-csf(粒细胞-巨噬细胞克隆刺激因子)应用的新领域。人和小鼠天然M-CSF为糖蛋白，由二硫键连接的同源双体，分子量40～90kDa。人和小鼠M-CSF分子这个区域结构高度保守，其同源性达80％。