CD59 monoclonal antibody, clone MEM-43 (FITC)
产品名称： CD59 monoclonal antibody, clone MEM-43 (FITC)
英文名称： CD59 monoclonal antibody, clone MEM-43 (FITC)
产品编号： MAB5010
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
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- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native CD59.
- Immunogen:
- Native purified CD59 from thymocytes and T lymphocytes.
- Host:
- Mouse
- Theoretical MW (kDa):
- 18-20
- Reactivity:
- Human
- Specificity:
- This antibody reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 KDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells; it is widely present on cells in all tissues.
- Form:
- Liquid
- Conjugation:
- FITC
- Isotype:
- IgG2a
- Storage Buffer:
- In PBS (0.2% BSA, 15 mM sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity.
Omidvar N, Wang EC, Brennan P, Longhi MP, Smith RA, Morgan BP.J Immunol. 2006 Mar 1;176(5):2915-23.
- 2.
- Incorporation of leucocyte GPI-anchored proteins and protein tyrosine kinases into lipid-rich membrane domains of COS-7 cells.
Cebecauer M, Cerny J, Horejsi V.Biochem Biophys Res Commun. 1998 Feb 24;243(3):706-10.
- 3.
- Mutational analysis of the active site and antibody epitopes of the complement-inhibitory glycoprotein, CD59.
Bodian DL, Davis SJ, Morgan BP, Rushmere NK.J Exp Med. 1997 Feb 3;185(3):507-16.
- Application Image
- Flow Cytometry
- Entrez GeneID:
- 966
- Gene Name:
- CD59
- Gene Alias:
- 16.3A5,1F5,EJ16,EJ30,EL32,FLJ38134,FLJ92039,G344,HRF-20,HRF20,MAC-IP,MACIF,MEM43,MGC2354,MIC11,MIN1,MIN2,MIN3,MIRL,MSK21,p18-20
- Gene Description:
- CD59 molecule, complement regulatory protein
- Omim ID:
- 107271
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq
- Other Designations:
- 20 kDa homologous restriction factor,CD59 antigen,CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344),CD59 glycoprotein,Ly-6-like protein,T cell-activating protein,human leukocyte antigen MIC11,lymphocytic a