BCL2 like 14,Bcl2样凋亡蛋白14抗体

产品编号HZ-7585R
英文名称BCL2 like 14
中文名称Bcl2样凋亡蛋白14抗体
别 名Apoptosis facilitator Bcl 2 like 14 protein; Apoptosis facilitator Bcl 2 like protein 14; Apoptosis regulator Bcl G; Bcl2 L 14; BCL2 like 14 (apoptosis facilitator); BCL2 like 14; BCL2L14; BCLG; B2L14_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞凋亡 细胞类型标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Horse, Rabbit,
BCL2 like 14,Bcl2样凋亡蛋白14抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量37kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Bcl G/BCL2 like 14 (265-301aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
BCL2 like 14,Bcl2样凋亡蛋白14抗体PubMedPubMed
产品介绍background:
Bcl-G is a novel pro-apoptotic member of the Bcl-2 family. The human Bcl-G gene encodes two proteins through alternative mRNA splicing, Bcl-G(L) (long) and Bcl-G(S) (short) consisting of 327 and 252 amino acids in length, respectively. Bcl-G(L) mRNA is expressed widely in adult human tissues, whereas Bcl-G(S) mRNA was found only in testis. Overexpression of Bcl-G(L) or Bcl-G(S) in cells induced apoptosis although Bcl-G(S) was far more potent than Bcl-G(L).

Function:
Plays a role in apoptosis.

Subunit:

BCL2 like 14,Bcl2样凋亡蛋白14抗体Subcellular Location:
Cytoplasm.
Isoform 1: Cytoplasm, cytosol. Note=Diffusely distributed throughout the cytosol.
Isoform 2: Endomembrane system. Note=Predominantly localized to cytosolic organelles.

Tissue Specificity:
Isoform 1 is widely expressed. Isoform 2 is testis-specific.

Post-translational modifications:
Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.

DISEASE:

Similarity:
Belongs to the Bcl-2 family.

Database links:
UniProtKB/Swiss-Prot: Q9BZR8.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.