FITC标记的凝血因子7抗体-抗体-抗体-生物在线
上海沪震实业有限公司
FITC标记的凝血因子7抗体

FITC标记的凝血因子7抗体

商家询价

产品名称： FITC标记的凝血因子7抗体

英文名称： Anti-Factor VII heavy chain/FITC

产品编号： HZ-4846R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： IF=1:50-200

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 Rabbit Anti-Factor VII heavy chain/FITC Conjugated antibody

FITC标记的凝血因子7抗体

 

产品编号 bs-4846R-FITC
英文名称 Anti-Factor VII heavy chain/FITC
中文名称 FITC标记的凝血因子7抗体
别    名 Factor VII heavy chain; coagulation factor VII (serum prothrombin conversion accelerator); Coagulation factor VII; Eptacog alfa; F7; FA7_HUMAN; Factor VII; Factor VII light chain; FVII coagulation protein; OTTHUMP00000018733; OTTHUMP00000018734; Proconvertin; Serum prothrombin conversion accelerator; SPCA.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 17/28kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Factor VII heavy chain
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

Function:
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium. 

Subunit:
Heterodimer of a light chain and a heavy chain linked by a disulfide bond. 

Subcellular Location:
Secreted. 

Tissue Specificity:
Plasma.

Post-translational modifications:
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. 
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. 

DISEASE:
Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:227500]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. 

Similarity:
Belongs to the peptidase S1 family. 
Contains 2 EGF-like domains. 
Contains 1 Gla (gamma-carboxy-glutamate) domain. 
Contains 1 peptidase S1 domain.

Database links:

Entrez Gene: 2155 Human

Omim: 613878 Human

SwissProt: P08709 Human

Unigene: 36989 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

凝血因子7是肝脏合成的一种维生素K依赖性的单链糖蛋白,由4 0 6个氨基酸残基组成,分子量约45kD。 凝血因子Ⅶ的半衰期最短（4～6h），血浆含量较低（0.5～2mg/L），故可作为肝病患者蛋白质合成功能减退的早期诊断指标。在慢性肝病患者通过肝活检组织原位杂交的方法检测到凝血因子Ⅶ的表达与肝纤维化的分级呈负相关，可作为预测纤维化程度的指标。凝血因子Ⅶ活性还与预后有着密切的联系，经研究认为：凝血因子Ⅶ活性<34%的肝硬化患者93%在随访10月内死亡，故认为它是肝硬化患者预后好坏的早期预测指标，可更好识别肝移植候选人。肝硬化患者凝血因子Ⅶ活性可明显下降，凝血因子Ⅶ缺乏可导致血小板活性的改变，结合血小板计数减少使出血时间延长，因此对有创诊断与治疗的肝硬化患者，还应该用凝血因子Ⅶ活性进行出血危险度的评估，而不能仅看血小板计数。除诊断之外，重组凝血因子Ⅶ可以有效地纠正肝病患者凝血异常，有利于有创性检查的进行
   

引发血液凝固的外在途径。Serine蛋白酶在血液中以酶原形式循环。因子VII通过因子Xa、因子XIIa、因子IXA或凝血酶通过小蛋白水解转化为因子VIIa。在组织因子和钙离子的存在下，因子VIIa然后通过有限的蛋白水解将因子X转换为因子XA。因子VIIa也将转化因子Ⅸ因子IXA在组织因子和钙的存在下。