CLPS,胰辅脂酶抗体

产品编号HZ-10104R
英文名称CLPS
中文名称胰辅脂酶抗体
别 名Colipase; Colipase pancreatic; Pancreatic colipase preproprotein; COL_RAT; COL_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 内分泌病
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,
CLPS,胰辅脂酶抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量10kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from rat CLPS
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CLPS,胰辅脂酶抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Function:
Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.

Subunit:
Forms a 1:1 stoichiometric complex with pancreatic lipase.

Subcellular Location:
Secreted.

Post-translational modifications:
Expressed by the pancreas.

Similarity:
Belongs to the colipase family.

Gene ID:
25680

CLPS,胰辅脂酶抗体Database links:
Entrez Gene: 1208 Human
Omim: 120105 Human
SwissProt: P04118 Human
Unigene: 1340 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.