APBB3,铁蛋白Fe65样蛋白2抗体

产品编号HZ-11637R
英文名称APBB3
中文名称铁蛋白Fe65样蛋白2抗体
别 名FE65L2; Amyloid beta A4 precursor protein binding family B member 3; Amyloid beta A4 precursor protein-binding family B member 3; amyloid beta precursor protein binding family B member 3; amyloid precursor interacting protein; Apbb3; APBB3_HUMAN; Fe65 like protein 2; FE65L2; Protein Fe65-like 2; SRA.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 Alzheimer's
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Sheep,
APBB3,铁蛋白Fe65样蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量52kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human APBB3/FE65L2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
APBB3,铁蛋白Fe65样蛋白2抗体PubMedPubMed
产品介绍background:
Fe65L2 is a 486 amino acid protein that contains one WW domain and two PID domains. Binding to the intracellular domain of the ∫-Amyloid precursor protein, Fe65L2 is thought to modulate the internalization and, therefore, the accessibility and function of ∫-Amyloid. Via its ability to control the intracellular accumulation of ∫-Amyloid, Fe65L2 is thought to play a role in the pathogenesis of Alzheimer's disease. Fe65L2 exists as four alternatively spliced isoforms designated isoform I, isoform II, isoform III and isoform IV. Fe65L2 interacts with Amyloid-like protein and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Function:
May modulate the internalization of beta-amyloid precursor protein.

Subunit:
Binds to the intracellular domain of the beta-amyloid precursor protein. Also binds to APP-like proteins.

Tissue Specificity:
Expressed in various tissues.

Similarity:
Contains 2 PID domains.
Contains 1 WW domain.

APBB3,铁蛋白Fe65样蛋白2抗体Database links:
Entrez Gene: 10307 Human
Entrez Gene: 225372 Mouse
Entrez Gene: 117026 Rat
Omim: 602711 Human
SwissProt: O95704 Human
SwissProt: Q8R1C9 Mouse
SwissProt: O35827 Rat
Unigene: 529449 Human
Unigene: 89673 Mouse
Unigene: 30067 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.