MYCBP2,MYC结合蛋白2抗体

产品编号HZ-9375R
英文名称MYCBP2
中文名称MYC结合蛋白2抗体
别 名Pam/highwire/rpm-1 protein; Phr1; MYC binding protein 2; PAM; Pam, highwire, rpm 1; Protein associated with Myc; Probable E3 ubiquitin-protein ligase MYCBP2; Myc-binding protein 2; Pam/highwire/rpm-1 protein; Protein associated with Myc; MYCB2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细胞周期蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse, Sheep,
MYCBP2,MYC结合蛋白2抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量510kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MYCBP2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MYCBP2,MYC结合蛋白2抗体PubMedPubMed
产品介绍background:
MYCBP2 belongs to the highwire family. It is a probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. MYCBP2 may function as a facilitator or regulator of transcriptional activation by MYC and have a role during synaptogenesis. There are two different isoforms.

Function:
Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis.

Subunit:
Interacts with MYC. Interacts with TSC2 (tuberin) when TSC2 is in complex with TSC1 (hamartin). Interacts with FBXO45.

Subcellular Location:
Nuclear

Tissue Specificity:
Expressed in all tissues examined, expression is exceptionally abundant in brain and thymus. Colocalizes with TSC1 and TSC2 along the neurites and in the growth cones. Colocalized with TSC1 in one of the filopodial extensions at the tip of a growth cone.

MYCBP2,MYC结合蛋白2抗体Similarity:
Belongs to the highwire family.
Contains 1 B box-type zinc finger.
Contains 1 DOC domain.
Contains 1 filamin repeat.
Contains 5 RCC1 repeats.
Contains 1 RING-type zinc finger.

Gene ID:
23077

Database links:
Entrez Gene: 23077 Human
Entrez Gene: 105689 Mouse
Entrez Gene: 290447 Rat
Omim: 610392 Human
SwissProt: O75592 Human
SwissProt: Q7TPH6 Mouse

MYCBP2,MYC结合蛋白2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.