Cytokeratin 6,细胞角蛋白6抗体

产品编号HZ-10105R
英文名称Cytokeratin 6
中文名称细胞角蛋白6抗体
别 名KRT6A; CK6A; CK6B; CK6C; CK6D; CK 6E; K6A; CK6； K6C; K6D; KRT6C; Cytokeratin 6a; Cytokeratin 6B; Cytokeratin 6C; Cytokeratin 6D; Cytokeratin 6E; Cytokeratin6; Cytokeratin 6; k6a keratin; K6B; K6b keratin; K6c keratin; K6d keratin; K6e keratin; k6hf; Keratin 6 isoform K6e; Keratin 6C; Keratin 6E; Keratin K6h; Keratin type II cytoskeletal 6A; Keratin type II cytoskeletal 6B; Keratin type II cytoskeletal 6C; Keratin type II cytoskeletal 6D; Keratin type II cytoskeletal 6E; KRT6; KRT6A; KRT6B; KRT6C; KRT6D; KRT6E; MGC102925; K2C6A_HUMAN.
说 明 书0.1ml 0.2ml
研究领域
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
Cytokeratin 6,细胞角蛋白6抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量60kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Cytokeratin 6
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Cytokeratin 6,细胞角蛋白6抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin(KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq].

Subunit:
Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17. Interacts with TCHP.

Tissue Specificity:
Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.

DISEASE:

Similarity:
Belongs to the intermediate filament family.

Gene ID:
286887

Database links:
Entrez Gene: 286887 Human
Entrez Gene: 3853 Human
Entrez Gene: 3854 Human
Entrez Gene: 16687 Mouse
Entrez Gene: 16688 Mouse
Omim: 148041 Human
Omim: 148042 Human
Omim: 612315 Human
SwissProt: P02538 Human
SwissProt: P04259 Human
SwissProt: P48668 Human
SwissProt: P50446 Mouse
SwissProt: Q9Z331 Mouse
Unigene: 700779 Human
Unigene: 709234 Human

Cytokeratin 6,细胞角蛋白6抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.