ATAXIN 2 抗体
Applications
| In-house applications |
ELISA, IHC, IF, WB, IP Application not tested? Please see our Guarantee. |
| Published applications |
IF, WB |
Publications |
2 citations –view here |
| Species specificity |
Human,Mouse,Rat; other species not tested. |
| Published Species |
Mouse |
|
Images
Prev12Next
 HeLa cells were subjected to SDS PAGE followed by western blot with 21776-1-AP(ATXN2 antibody) at dilution of 1:1000 Immunohistochemical of paraffin-embedded human gliomas using 21776-1-AP(ATXN2 antibody) at dilution of 1:50 (under 10x lens) Immunohistochemical of paraffin-embedded human gliomas using 21776-1-AP(ATXN2 antibody) at dilution of 1:50 (under 40x lens) Immunofluorescent analysis of 293 cells, using ATXN2 antibody 21776-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). IP Result of anti-Ataxin 2 (IP:21776-1-AP, 4ug; Detection:21776-1-AP 1:1000) with HEK-293 cells lysate 1200ug.
|
| Positive WB detected in |
HeLa cells, DU 145 cells, HEK-293 cells |
| Positive IP detected in |
HEK-293 cells |
| Positive IHC detected in |
Human gliomas tissue |
| Positive IF detected in |
HepG2 cells, Ethacrynic acid treated HepG2 cells |
| Recommended dilution |
WB : 1:500-1:5000
IP : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:10-1:100 |
ATAXIN 2 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen |
Ataxin 2 fusion protein ag16470 |
Full name |
Ataxin 2 |
Calculated molecular
weight |
1313aa,140 kDa |
Observed molecular
weight |
140-150 kDa |
GenBank accession
number |
BC114546 |
Gene ID (NCBI) |
6311 |
| Gene symbol |
ATXN2 |
Synonyms |
Ataxin 2, ATX2, ATXN2, FLJ46772, SCA2, TNRC13 |
Background ATAXIN 2 抗体
|
ATXN2 contains a repeat structure with 22 or 23 triplets coding for glutamine and the (CAG)8CAA(CAG)4CAA(CAG)8 sequence; expansion of this domain to a size ≥34 triplets with a pure CAG sequence primarily causes autosomal dominant SCA2 [PMID:18418684], while ATXN2 expansions with CAA interruptions were observed as the cause of Levo-dopa responsive Parkinson’s disease [PMID:10668726]. ATXN2 expansions associated with ALS were reported to be interrupted by at least one CAA triplet [PMID:21537950]. ATAXIN 2 抗体
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