分子量:56.2 kDa

纯度:>92% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human CLEC10A, Fc Tag by the LAL method.

Buffer:50 mM tris, 100 mM glycine, pH7.5

生物活性:

产品特性:Human CLEC10A, Fc Tag is fused with a human IgG1 Fc tag at the N-terminus, and has a calculated MW of 56.2 kDa. The predicted N-terminus is Glu. The reducing (R) protein migrates as 60-75 kDa in SDS-PAGE  due to glycosylation.

产品背景:C-type lectin domain family 10 member A (CLEC10A) is also known as C-type lectin superfamily member 14 (CLECSF14), Macrophage lectin 2, CD antigen CD301. CLEC10A / CD301 is a unique calcium-type (C-type) lectin, which expressed on Dendritic cells (DCs). CLEC10A / CD301 probable role in regulating adaptive and innate immune responses. CLEC10A / CD301 binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine (GalNAc), linked to serine or threonine. There are two homologues in mice: MGL1 and MGL2 (CD301a and CD301b).