DPPA5,多能发育相关基因5抗体

产品编号HZ-12192R
英文名称DPPA5
中文名称多能发育相关基因5抗体
别 名Developmental pluripotency associated 5; DPPA5; Embryonal stem cell specific gene 1 protein; Esg 1; ESG1; hDPPA5; DPPA5_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 干细胞
抗体来源Rabbit
克隆类型Polyclonal
DPPA5,多能发育相关基因5抗体交叉反应Human, Mouse, Rat, Rabbit,
产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量13kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from Human DPPA5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DPPA5,多能发育相关基因5抗体PubMedPubMed
产品介绍background:
DPPA5 is a 116 amino acid protein that localizes to the cytoplasm and contains one KH domain. Expressed in embryonic germ (EG), primordial germ (PG) and embryonic stem (ES) cells, DPPA5 plays an important role in the maintenance of ES cell pluripotency and may be necessary for proper embryogenesis. The gene encoding DPPA5 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

Function:
Dppa5 (sometimes known as Esg1) is expressed in mouse and human pluripotent cells and can be used as a marker of these cell types (Kim et al., 2005).

Subcellular Location:
Cytoplasmic

Similarity:
Belongs to the KHDC1 family.
Contains 1 KH domain.

Database links:
UniProtKB/Swiss-Prot: A6NC42.1

DPPA5,多能发育相关基因5抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.