NF1 (phospho S2741) polyclonal antibody
产品名称： NF1 (phospho S2741) polyclonal antibody
英文名称： NF1 (phospho S2741) polyclonal antibody
产品编号： PAB12637
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of NF1.
- Immunogen:
- Synthetic phosphopeptide corresponding to residues surrounding S2741 of human NF1.
- Sequence:
- PTSPY
- Host:
- Rabbit
- Theoretical MW (kDa):
- 240
- Reactivity:
- Bovine, Dog, Human, Mouse, Rat
- Specificity:
- This antibody recognizes ~240 KDa of human NF1 at the phosphorylation site of Ser 2741. It does not cross react to non-phospho NF1.
- Form:
- Liquid
- Storage Buffer:
- In TBS, pH 7.2 (10% Proclin300)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Phosphorylation of neurofibromin by cAMP-dependent protein kinase is regulated via a cellular association of N(G),N(G)-dimethylarginine dimethylaminohydrolase.
Tokuo H, Yunoue S, Feng L, Kimoto M, Tsuji H, Ono T, Saya H, Araki N.FEBS Lett. 2001 Apr 6;494(1-2):48-53.
- Applications
- Western Blot (Tissue lysate)
- The tissue lysates derived from hypoxic mouse brain were immunoblotted by NF1 (phospho S2741) polyclonal antibody (Cat # PAB12637) at 1 : 1000.
- Dot Blot (Peptide)
- Dot Blot : 1 ug peptide was blot onto NC membrane.
A : NF1 (pS2741).
B : NF1 (Non-phospho).
C : Non-related phospho-specific phophopeptide.
Followed were blotted at a 1 : 1000 dilution by :
1. NF1 (phospho S2741) polyclonal antibody (Cat # PAB12637).
2. NF1 polyclonal antibody (Cat # PAB12636).
- Entrez GeneID:
- 4763
- Gene Name:
- NF1
- Gene Alias:
- DKFZp686J1293,FLJ21220,NFNS,VRNF,WSS
- Gene Description:
- neurofibromin 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq
- Other Designations:
- neurofibromin
- Gene Pathway
- Related Disease
- Adrenal Gland Neoplasms
- Autistic Disorder
- Cardiovascular Diseases
- Craniofacial Abnormalities
- Diabetes Mellitus, Type 2
- Edema
- Epilepsy
- Facies
- Genetic Predisposition to Disease
- Growth Disorders
- Learning Disorders
- Leukemia, Myeloid, Acute
- Multiple endocrine neoplasia
- Myelodysplastic Syndromes
- Nerve Sheath Neoplasms
- Neurofibromatosis
- Neurofibromatosis 1
- Noonan Syndrome
- Pancreatic cancer