EDF1,内皮分化相关因子1抗体

产品编号HZ-14503R
英文名称EDF1
中文名称内皮分化相关因子1抗体
别 名CAP19; EDF-1; edf1; EDF1_HUMAN; Endothelial differentiation related factor 1; Endothelial differentiation-related factor 1; MBF1; MGC9058; Multiprotein bridging factor 1; Multiprotein-bridging factor 1.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 信号转导 转录调节因子 细胞分化 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
EDF1,内皮分化相关因子1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量16kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EDF1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EDF1,内皮分化相关因子1抗体PubMedPubMed
产品介绍background:
This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Function:
Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.

Subunit:

Subcellular Location:
Cytoplasm. Nucleus. Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.

EDF1,内皮分化相关因子1抗体Tissue Specificity:
Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues.

Post-translational modifications:
Phosphorylated (by PKA and PKC).

DISEASE:

Similarity:
Contains 1 HTH cro/C1-type DNA-binding domain.

Gene ID:
8721

Database links:
Entrez Gene: 8721 Human
Entrez Gene: 417286 Chicken
Entrez Gene: 515380 Cow
Entrez Gene: 59022 Mouse
Entrez Gene: 296570 Rat
Omim: 605107 Human
SwissProt: Q3T0V7 Cow
SwissProt: O60869 Human
SwissProt: Q9JMG1 Mouse
SwissProt: P69736 Rat
Unigene: 174050 Human
Unigene: 29945 Mouse
Unigene: 17092 Rat

EDF1,内皮分化相关因子1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.