FAM76B,FAM76B蛋白抗体

产品编号HZ-9659R
英文名称FAM76B
中文名称FAM76B蛋白抗体
别 名Family with sequence similarity 76 member B; Hypothetical protein LOC143684; MGC33371; FA76B_HUMAN.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 发育生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
FAM76B,FAM76B蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FAM76B
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FAM76B,FAM76B蛋白抗体PubMedPubMed
产品介绍background:
With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and β thalassemia are caused by HBB gene mutations. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11. The FAM76B gene product has been provisionally designated FAM76B pending further characterization.

Subcellular Location:
Nucleus speckle.

Post-translational modifications:
Isoform 2 is ubiquitinated at Lys-225.
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the FAM76 family.

Database links:
Entrez Gene: 143684 Human
Entrez Gene: 72826 Mouse
Entrez Gene: 367021 Rat
SwissProt: Q5HYJ3 Human
SwissProt: Q80XP8 Mouse

FAM76B,FAM76B蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片	Protein: bone lyates(mo);  Primary: Rabbit Anti- FAM76B (HZ-9659R) at 1:300;  Secondary: 800CW Conjugated Goat (polyclonal) Anti-Rabbit IgG(H+L) at 1: 10000;  Predicted band size:39 kD Observed band size:39 kD