DUSP3 polyclonal antibody
产品名称： DUSP3 polyclonal antibody
英文名称： DUSP3 polyclonal antibody
产品编号： PAB4125
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against full length recombinant DUSP3.
- Immunogen:
- Recombinant protein corresponding to full length human DUSP3.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Crystal structure of the dual specificity protein phosphatase VHR.
Yuvaniyama J, Denu JM, Dixon JE, Saper MA.Science. 1996 May 31;272(5266):1328-31.
- 2.
- Expression cloning of a human dual-specificity phosphatase.
Ishibashi T, Bottaro DP, Chan A, Miki T, Aaronson SA.Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12170-4.
- Entrez GeneID:
- 1845
- Protein Accession#:
- P51452
- Gene Name:
- DUSP3
- Gene Alias:
- VHR
- Gene Description:
- dual specificity phosphatase 3
- Omim ID:
- 600183
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq
- Other Designations:
- serine/threonine specific protein phosphatase,vaccinia virus phosphatase VH1-related
- Gene Pathway