phospho-DAP Kinase 1 (Ser308),磷酸化凋亡相关蛋白激酶1抗体

产品编号HZ-12576R
英文名称phospho-DAP Kinase 1 (Ser308)
中文名称磷酸化凋亡相关蛋白激酶1抗体
别 名DAP Kinase 1 (phospho Ser308); DAP Kinase 1 (phospho S308); DAK1; DAP K1; DAP kinase 1; DAPK 1; DAPK; DAPK1; DAPK1_HUMAN; Death Associated Protein Kinase 1; Death-associated protein kinase 1; DKFZp781I035;
说 明 书0.1ml
产品类型磷酸化抗体
研究领域肿瘤 细胞生物 信号转导 细胞凋亡 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
phospho-DAP Kinase 1 (Ser308),磷酸化凋亡相关蛋白激酶1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量157kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human DAP Kinase 1 around the phosphorylation site of Ser308
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
phospho-DAP Kinase 1 (Ser308),磷酸化凋亡相关蛋白激酶1抗体PubMedPubMed
产品介绍background:
DAPK1 expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlates with high rates of metastasis. The loss of DAPK expression provides a link between suppression of apoptosis and metastasis. DAPK1 is thought be involved in an early apoptotic checkpoint which eliminates premalignant cells from cancer formation. Studies in bladder cancer patients have also shown that hypermethylation of DAPK1 correlates to high recurrence rates and thus DAPK1 may be used as a prognostic marker. DAPK1 is also reportedly a molecular regulator of neuronal death in epilepsy.

Function:
Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.

Subcellular Location:
Cytoplasm. Colocalizes with the actin filament system.

Post-translational modifications:
Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex, leading to its degradation by the proteasome.

Similarity:
Belongs to the protein kinase superfamily.
CAMK Ser/Thr protein kinase family.
DAP kinase subfamily.
Contains 10 ANK repeats.
Contains 1 death domain.
Contains 1 protein kinase domain.

Gene ID:
1612

Database links:
Entrez Gene: 1612 Human
Entrez Gene: 69635 Mouse
Entrez Gene: 306722 Rat
Omim: 600831 Human
SwissProt: P53355 Human
SwissProt: Q80YE7 Mouse
Unigene: 380277 Human
Unigene: 693441 Human

phospho-DAP Kinase 1 (Ser308),磷酸化凋亡相关蛋白激酶1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.