EGR4,早期生长反应蛋白4抗体

产品编号HZ-14522R
英文名称EGR4
中文名称早期生长反应蛋白4抗体
别 名AT133; EGR4_HUMAN； Early growth response protein 4; Nerve growth factor induced clone C; NGFI C; NGFIC; PAT133.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 转录调节因子 锌指蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse,
EGR4,早期生长反应蛋白4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量62kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EGR4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EGR4,早期生长反应蛋白4抗体PubMedPubMed
产品介绍background:
Egr-1, Egr-2, Egr-3 and Egr-4 are nuclear transcription factors belonging to the Egr C2H2-type zinc-finger protein family and containing three C2H2-type zinc fingers. As immediate early proteins, Egr transcription factors are rapidly induced by diverse extracellular stimuli. They are subject to tight differential control through diverse mechanisms at several levels of regulation: transcriptional; translational and posttranslational (including glycosylation, phosphorylation and redox) mechanisms; and protein-protein interaction. Egr-1 binds to the DNA sequence 5'-CGCCCCCGC-3' (Egr-site), thereby activating transcription of target genes whose products are required for mitogenisis and differentiation. Egr-2 binds specific DNA sites located in the promoter region of HoxA4. Egr-2 defects cause congenital hypomyelination neuropathy (also designated Charcot-Marie-Tooth disease) and Dejerine-Sottas neuropathology (also designated hereditary motor and sensory neuropathy III). Egr-3 is involved in muscle spindle development and is expressed in T cells 20 minutes following activation. Egr-4 binds to the Egr consensus motif GCGTGGGCG, functions as a transcriptional repressor, and displays autoregulatory activities, downregulating its own gene promoter in a dose dependent manner.

Function:
EGR4(Early Growth Response protein 4) is a zinc-finger transcription factor that activates the transcription of genes whose products are required for mitogenesis and differentiation. EGR4 is closely related to nerve growth factor-induced clone A (NGFI-A or EGR1), EGR2, and EGR3. These four early response (immediate early) proteins all contain very similar zinc-finger DNA binding domains and five highly homologous subdomains. EGR4 functionally cooperate with NFAT proteins and induce expression of IL2 and TNFalpha. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.

Subunit:

EGR4,早期生长反应蛋白4抗体Subcellular Location:
Nuclear

Tissue Specificity:

DISEASE:

Similarity:
Belongs to the EGR C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.

Gene ID:
1961

Database links:
Entrez Gene: 1961 Human
Entrez Gene: 407155 Cow
Entrez Gene: 13656 Mouse
Entrez Gene: 25129 Rat
Omim: 128992 Human
SwissProt: Q9GL32 Cow
SwissProt: Q05215 Human
SwissProt: Q9WUF2 Mouse
SwissProt: Q00911 Rat
Unigene: 3052 Human

EGR4,早期生长反应蛋白4抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.