FITC标记的髓细胞性白血病蛋白1抗体
产品名称： FITC标记的髓细胞性白血病蛋白1抗体
英文名称： Anti-MLF1/MLF2 /FITC
产品编号： HZ-9179R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-MLF1/MLF2 /FITC Conjugated antibody
FITC标记的髓细胞性白血病蛋白1抗体
| 产品编号 | bs-9179R-FITC |
| 英文名称 | Anti-MLF1/MLF2 /FITC |
| 中文名称 | FITC标记的髓细胞性白血病蛋白1抗体 |
| 别 名 | Hls7; MLF1; MLF2; MLF3; MLF1_HUMAN; Myelodysplasia myeloid leukemia factor 1; Myelodysplasia-myeloid leukemia factor 1; Myeloid leukemia factor 1; myeloid leukemia factor 1 variant 1; myeloid leukemia factor 1 variant 2; myeloid leukemia factor 1 variant 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 免疫学 染色质和核信号 信号转导 干细胞 细胞周期蛋白 细胞分化 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MLF1/2/3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. Function: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. Subunit: Interacts with MLF1IP. Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP. NRBP1 recruits a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then binds to YWHAZ and is retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2. Binds to COPS3/CSN3 which is required for suppression of RFWD2 and activation of p53. Subcellular Location: Cytoplasm. Nucleus. In non-hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM. Tissue Specificity: Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes. Post-translational modifications: Phosphorylation is required for binding to YWHAZ (By similarity). DISEASE: Note=A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM. Similarity: Belongs to the MLF family. Database links: Entrez Gene: 79682 Human Entrez Gene: 71876 Mouse Entrez Gene: 306464 Rat Omim: 611511 Human SwissProt: Q2KIW5 Cow SwissProt: Q71F23 Human SwissProt: Q8C4M7 Mouse SwissProt: Q4V8G7 Rat Unigene: 575032 Human Unigene: 217385 Mouse Unigene: 22108 Mouse Unigene: 128609 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
通过限制红系形成和增强髓系形成参与初级造血祖细胞的谱系承诺。通过抑制CDKN1B/p27kip1水平，阻止促红细胞生成素诱导红细胞终末分化，防止细胞离开细胞周期。通过cSN3抑制rFWD2/COP1活性，激活p53并诱导细胞周期阻滞。结合DNA并影响许多基因的表达，从而在细胞核中起转录因子的作用。