PCDH18,原钙粘附蛋白18抗体

产品编号HZ-11112R
英文名称PCDH18
中文名称原钙粘附蛋白18抗体
别 名PCD18_HUMAN; PCDH18; PCDH68L; protocadherin 18; protocadherin 68-like protein; Protocadherin-18.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 细胞粘附分子 细胞外基质 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
PCDH18,原钙粘附蛋白18抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量123kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PCDH18
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PCDH18,原钙粘附蛋白18抗体PubMedPubMed
产品介绍background:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDH18 (protocadherin 18), also known as PCDH68L, is a 1,135 amino acid single-pass type I cell membrane protein that contains six cadherin domains and a cytoplasmic tail that differs from classical cadherins. Expressed ubiquitously with highest expression in ovary and lung, PCDH18 interacts with Dab1 and functions as a potential calcium-dependent adhesion protein that may be involved in the establishment of cell-cell connections in the brain. Multiple isoforms of PCDH18 exist due to alternative splicing events.

Function:
Potential calcium-dependent cell-adhesion protein.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expressed in all tissues, with highest expression in lung and ovary.

PCDH18,原钙粘附蛋白18抗体Similarity:
Contains 6 cadherin domains.

Database links:
UniProtKB/Swiss-Prot: Q9HCL0.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.