FITC标记的丝裂原活化蛋白激酶活化的蛋白激酶3抗体
产品名称： FITC标记的丝裂原活化蛋白激酶活化的蛋白激酶3抗体
英文名称： Anti-MAPKAP3/FITC
产品编号： HZ-18673R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MAPKAP3/FITC Conjugated antibody
FITC标记的丝裂原活化蛋白激酶活化的蛋白激酶3抗体
| 英文名称 | Anti-MAPKAP3/FITC |
| 中文名称 | FITC标记的丝裂原活化蛋白激酶活化的蛋白激酶3抗体 |
| 别 名 | 3pK; anti MAPKAPK3; Chromosome 3p kinase; EC 2.7.11.1; MAP kinase-activated protein kinase 3; MAPK activated protein kinase 3; MAPK-activated protein kinase 3; MAPK3_HUMAN; MAPKAP; MAPKAP kinase 3; MAPKAP-K3; MAPKAP3; MAPKAPK 3; MAPKAPK-3; Mapkapk3; MAPKAPK3; ; Mitogen activated protein kinase activated protein kinase 3; Mitogen activated protein kinase activated protein kinase; MK-3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MAPKAP3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Subcellular Location: Nucleus. Cytoplasm. Predominantly located in the nucleus, when activated it translocates to the cytoplasm. Tissue Specificity: Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain. Post-translational modifications: Phosphorylated and activated by MAPK1/ERK2 and MAPK3/ERK1. Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-201, Ser-251 and Thr-313. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Contains 1 protein kinase domain. Database links: Entrez Gene: 615215 Cow Entrez Gene: 7867 Human Entrez Gene: 102626 Mouse Entrez Gene: 315994 Rat Omim: 602130 Human SwissProt: Q3SYZ2 Cow SwissProt: Q16644 Human SwissProt: Q3UMW7 Mouse SwissProt: Q66H84 Rat Unigene: 234521 Human Unigene: 735013 Human Unigene: 222612 Mouse Unigene: 445242 Mouse Unigene: 8789 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码SR/THR蛋白激酶家族的成员。该激酶起丝裂原活化蛋白激酶（MAP激酶）活化蛋白激酶的作用。MAP激酶也被称为细胞外信号调节激酶（ERK），作为多种生化信号的整合点。该激酶通过生长诱导剂和细胞应激刺激而被激活。体外研究表明，ERK、p38 MAP激酶和Jun N端激酶均能磷酸化并激活该激酶，提示该激酶在有丝分裂原和应激反应中作为信号传导的一体元件。据报道，该激酶与E47相互作用，磷酸化并抑制其活性，E47是已知的参与调节组织特异性基因表达和细胞分化的基本螺旋-环-螺旋转录因子。交替剪接导致编码同一蛋白质的多个转录变体。[ RefSeq，SEP 2011提供]