FITC标记的FBXL21蛋白抗体
产品名称： FITC标记的FBXL21蛋白抗体
英文名称： Anti-FBXL21/FITC
产品编号： HZ-8476R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FBXL21/FITC Conjugated antibody
FITC标记的FBXL21蛋白抗体
| 产品编号 | bs-8476R-FITC |
| 英文名称 | Anti-FBXL21/FITC |
| 中文名称 | FITC标记的FBXL21蛋白抗体 |
| 别 名 | F box and leucine rich repeat protein 21; F box and leucine rich repeat protein 3 pseudogene; F box and leucine rich repeat protein 3B; F box protein Fbl3b; F box/LRR repeat protein 21; F box/LRR repeat protein 3B; Fbl 21; FBXL 21; FBXL-21; FBL 3; FBL 3B; Fbl21; FBL3; FBL-3B; FBL 3B; FBL3B; FBXL 21; FBXL 3B; FBXL 3P; FBXL3B; FBXL3P; MGC120237; FXL21_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞周期蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FBXL21/FBL3B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FBL3B is a 434 amino acid protein encoded by the human gene FBXL21. FBL3B contains one 40 amino acid F-box region, making it a member of the F-box family. FBL3B also contains three LRR (leucine-rich) repeats. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. F-box proteins are members of a large family that regulates cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. FBL3B is a substrate-recognition component of the SCF complex that interacts with Skp1 p19 and CUL-1. FBL3B is also associated with expression and regulation of circadian and cryptochrome proteins. Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex involved in circadian pacemaker function. The SCF(FBXL21) complex acts by mediating ubiquitination and subsequent degradation of CRY1. Probable clock-controlled protein that plays a specific role in suprachiasmatic nucleus, SCN and pacemaker function. Subunit: Interacts with CRY1. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1. Similarity: Contains 1 F-box domain. Contains 7 LRR (leucine-rich) repeats. Database links: Entrez Gene: 26223 Human Omim: 609087 Human SwissProt: Q9UKT6 Human Unigene: 591275 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
FBL3B是由人基因FbxL21编码的434氨基酸蛋白。FBL3B包含一个40个氨基酸的F盒区域，使其成为F盒家族的成员。FBL3B还含有三个LRR（富含亮氨酸）重复序列。F-盒蛋白是SCF（SKP1-Cul-1-F盒蛋白）型E3泛素连接酶复合体的重要组成部分，参与了泛素化的底物识别和募集。F-盒蛋白是一个大家族的成员，它通过靶向蛋白质，如细胞周期蛋白，细胞周期蛋白依赖性激酶抑制剂，IKB-A和B-连环蛋白，通过泛素化后的蛋白酶体降解来调节细胞周期、免疫应答、信号级联和发育程序。FBL3B是与Skp1 P19和Cul-1相互作用的SCF复合物的底物识别成分。FBL3B还与昼夜节律蛋白和隐色素蛋白的表达和调节有关。