Mint3,β淀粉样前体蛋白结合蛋白3抗体

产品编号HZ-11058R
英文名称Mint3
中文名称β淀粉样前体蛋白结合蛋白3抗体
别 名Adapter protein X11gamma; amyloid beta (A4) precursor protein binding, family A, member 3; Amyloid beta precursor protein binding, family A, member 3 phosphotyrosine binding/ interacting domain (PTB) bearing protein; APBA3; lin 10; MGC:15815; Mint 3; Mint3; Mint-3; Neuron specific X11L2 protein; Neuronal Munc18 1 interacting protein 3; phosphotyrosine binding/interacting domain (PTB) bearing protein; X11 like 2 protein 2; X11gamma; X11L2; APBA3_RAT.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
Mint3,β淀粉样前体蛋白结合蛋白3抗体研究领域免疫学 神经生物学 细胞粘附分子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,
产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量63kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from Rat Mint3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Mint3,β淀粉样前体蛋白结合蛋白3抗体PubMedPubMed
产品介绍background:
The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the Beta-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11 Alpha (also designated Mint 1), X11 Beta (Mint 2) and X11 (Mint 3).

Function:
May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).

Subunit:
Binds to the cytoplasmic domain of amyloid protein (APP). Interacts with HIF1AN (via N-terminus) (By similarity).

Subcellular Location:
Cytoplasm; perinuclear region.

Tissue Specificity:
Ubiquitous.

Similarity:
Contains 2 PDZ (DHR) domains.
Contains 1 PID domain.

Mint3,β淀粉样前体蛋白结合蛋白3抗体Database links:
Entrez Gene: 57267 Mouse
Entrez Gene: 83611 Rat
SwissProt: O88888 Mouse
SwissProt: O70248 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.