C2orf18,2号染色体开放阅读框18抗体

产品编号HZ-9805R
英文名称C2orf18
中文名称2号染色体开放阅读框18抗体
别 名ANT2 binding protein; ANT2BP; Chromosome 2 open reading frame 18; FLJ20555; S35F6_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 结合蛋白 线粒体
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
C2orf18,2号染色体开放阅读框18抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 IEM=1:20-200 IGS=1:20-200 GICA=1:20-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量38kDa
细胞定位细胞浆 细胞膜 线粒体
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human C2orf18/ANT2BP
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
C2orf18,2号染色体开放阅读框18抗体PubMedPubMed
产品介绍background:
C2orf18 is a 371 amino acid multi-pass membrane protein that contains one DUF6 domain and is encoded by a gene that maps to human chromosome 2p23.3. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr鰉 syndrome, is related to mutations in the ALMS1 gene. Chromosome 2 contains a probable vestigial second centromere as well as vestigial telomeres, which gives credence to the hypothesis that human chromosome 2 formed as a result of an ancient fusion of two ancestral chromosomes, which are still present in modern day apes.

Function:
Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.

Subunit:
Interacts with SLC25A5.

Subcellular Location:
Mitochondrion. Lysosome membrane; Multi-pass membrane protein.

C2orf18,2号染色体开放阅读框18抗体Tissue Specificity:
Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in prostate and thyroid. Weakly expressed in lung, heart, liver and kidney.

Similarity:
Belongs to the SLC35F solute transporter family.
Contains 1 EamA domain.

Gene ID:
54978

Database links:
Entrez Gene: 54978 Human
SwissProt: Q8N357 Human
SwissProt: Q8VE96 Mouse
SwissProt: Q5RKH7 Rat
Unigene: 516034 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.