TXNDC11,硫氧还蛋白11抗体

产品编号HZ-11439R
英文名称TXNDC11
中文名称硫氧还蛋白11抗体
别 名EF-hand-binding protein 1; EFP1; RGD1307538; Thioredoxin domain-containing protein 11; TXD11_HUMAN; TXNDC11; 2810408E11Rik; AI427833.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 信号转导 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
TXNDC11,硫氧还蛋白11抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量110kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human TXNDC11
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
TXNDC11,硫氧还蛋白11抗体PubMedPubMed
产品介绍background:
May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.

Function:
May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.

Subunit:
Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA.

Subcellular Location:
Endoplasmic reticulum membrane.

Tissue Specificity:
Widely expressed at low level. Expressed at higher level in thyroid and prostate.

Similarity:
Belongs to the protein disulfide isomerase family.
Contains 2 thioredoxin domains.

Gene ID:
51061

Database links:
Entrez Gene: 490003 Dog
Entrez Gene: 100056118 Horse
Entrez Gene: 51061 Human
SwissProt: Q6PKC3 Human
Unigene: 313847 Human

TXNDC11,硫氧还蛋白11抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片

Paraformaldehyde-fixed, paraffin embedded (thyroid); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TXNDC11) Polyclonal Antibody, Unconjugated (HZ-11439R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TXNDC11) Polyclonal Antibody, Unconjugated (HZ-11439R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.