AGRP,褐黑素相关蛋白ART抗体

产品编号HZ-11415R
英文名称AGRP
中文名称褐黑素相关蛋白ART抗体
别 名Agouti Related Protein Homolog; agouti signaling protein; agouti switch protein; Agouti-related protein; Agrp; AGRP_HUMAN; AGRT; ART; ASIP2.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 神经生物学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,
AGRP,褐黑素相关蛋白ART抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量12kDa
细胞定位细胞浆 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human AGRP (31-80aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
AGRP,褐黑素相关蛋白ART抗体PubMedPubMed
产品介绍background:
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.

Function:
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.

Subunit:
Interacts with melanocortin receptors MC3R, MC4R and MC5R.

Subcellular Location:
Secreted. Golgi apparatus lumen.

AGRP,褐黑素相关蛋白ART抗体Tissue Specificity:
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.

DISEASE:
Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

Similarity:
Contains 1 agouti domain.

Database links:
UniProtKB/Swiss-Prot: O00253.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.