• 经测试应用IHC-Fr, WB, IHC-Pmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat, Cow, Cat
• 免疫原

  Recombinant fragment: EVV EIIQATIIRQ NQALRLRARK ECWDRDGKER VTGEEWLVTT VGAYLPAVFE EVLDLVDAVI LTEKTALHLR ARRNFRDFRG VSRRTGEEWL VTVQDTEAHV PDVHEEVLGV VPITTLGPHN YCVILDPVGP DGKNQLGQKR VVKGEKSFFL QPGEQLEQGI QDVYVLSEQQ GLLLRALQPL EEGEDEEKVS, corresponding to amino acids 158-350 of Human MVP (AAH15623)

  Run BLAST with  Run BLAST with 
• 阳性对照
  • 293T, A431, H1299, HeLa, HepG2, MOLT4, A549 and Raji cells

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: 20% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
• 浓度50 µl 浓度为 1 mg/ml 
  
• 纯度Immunogen affinity purified
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Signal Transduction
   
  • Protein Trafficking
   
  • Nuclear Import / Export

  • Cancer
   
  • Drug resistance
   
  • Vault proteins

应用

靶标

• 功能Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
• 组织特异性Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
• 序列相似性Contains 9 MVP (vault) repeats.
• 结构域MVP 3 mediates interaction with PTEN.
  MVP 4 mediates interaction with PARP4.
• 翻译后修饰Phosphorylated on Tyr residues after EGF stimulation.
  Dephosphorylated by PTPN11.
• 细胞定位Cytoplasm. Nucleus > nuclear pore complex. 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
• Information by UniProt
• 数据库链接
  • Entrez Gene: 516456 Cow
  • Entrez Gene: 9961 Human
  • Entrez Gene: 78388 Mouse
  • Entrez Gene: 64681 Rat
  • Omim: 605088 Human
  • SwissProt: Q3SYU9 Cow
  • SwissProt: Q14764 Human
  • SwissProt: Q9EQK5 Mouse

  see all
• 别名
  • LRP antibody
  • Lung resistance related protein antibody
  • Lung resistance-related protein antibody

  see all

Anti-MVP antibody 图像

• 

  Western blot - MVP antibody (ab97311)
  Anti-MVP antibody (ab97311) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg
  
  Predicted band size : 99 kDa
  
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MVP antibody (ab97311)