CNBP/ZNF9,细胞核酸结合蛋白抗体

产品编号HZ-18516R
英文名称CNBP/ZNF9
中文名称细胞核酸结合蛋白抗体
别 名CCHC type zinc finger nucleic acid binding protein; Cellular nucleic acid binding protein; Cellular nucleic acid-binding protein; CNBP; CNBP_HUMAN; CNBP1; DM2; Erythroid differentiation related; PROMM; Proximal myotonic myopathy nucleic acid binding protein; RNF163; Sterol regulatory element binding protein; ZCCHC22; Zinc finger protein 273; Zinc finger protein 9 (a cellular retroviral nucleic acid binding protein); Zinc finger protein 9; ZNF9.
说 明 书0.1ml 0.2ml
研究领域免疫学 神经生物学 转录调节因子 锌指蛋白 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, Monkey,
CNBP/ZNF9,细胞核酸结合蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量19kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CNBP/ZNF9
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CNBP/ZNF9,细胞核酸结合蛋白抗体PubMedPubMed
产品介绍background:
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Single stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.

Subcellular Location:
Cytoplasm. Endoplasmic reticulum.

Tissue Specificity:
Present in all tissues examined.

DISEASE:
Defects in CNBP are the cause of dystrophia myotonica type 2 (DM2) [MIM:602668]; also known as proximal myotonic myopathy (PROMM). A multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases. Note=The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.

Similarity:
Contains 7 CCHC-type zinc fingers.

Gene ID:
7555

Database links:
Entrez Gene: 7555 Human
Entrez Gene: 395731 Chicken
Entrez Gene: 504831 Cow
Entrez Gene: 12785 Mouse
Entrez Gene: 64530 Rat
Entrez Gene: 399294 Xenopus laevis
Omim: 116955 Human
SwissProt: O42395 Chicken
SwissProt: Q3T0Q6 Cow
SwissProt: P62633 Human
SwissProt: P53996 Mouse
SwissProt: P62634 Rat
Unigene: 518249 Human
Unigene: 290251 Mouse
Unigene: 6187 Rat

CNBP/ZNF9,细胞核酸结合蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.