分子量:44.2 kDa

纯度:>92% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human CEACAM-1, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human CEACAM-1, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 44.2 kDa. The predicted N-terminus is Gln 35. The reducing (R) protein migrates as 60-130 kDa in SDS-PAGE  due to different glycosylation.

产品背景:Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is also known as Biliary glycoprotein 1 (BGP1), CD66a,  which belongs to the immunoglobulin superfamily or CEA family. CEACAM1 /CD66a contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CEACAM1 /CD66a was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 / BGP-1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.