FITC标记的Focadhesin蛋白抗体
产品名称： FITC标记的Focadhesin蛋白抗体
英文名称： Anti-Focadhesin/FITC
产品编号： HZ--16158R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Focadhesin/FITC Conjugated antibody
FITC标记的Focadhesin蛋白抗体
| 英文名称 | Anti-Focadhesin/FITC |
| 中文名称 | FITC标记的Focadhesin蛋白抗体 |
| 别 名 | FOCAD; FOCAD_HUMAN; Focadhesin; KIAA1797. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 发育生物学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 200kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Focadhesin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Chromosome 9 consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. The KIAA1797 gene product has been provisionally designated KIAA1797 pending further characterization. Function: Potential tumor suppressor in gliomas. Subunit: Interacts with VCL. Subcellular Location: Membrane. Cell junction; focal adhesion. Colocalizes with VCL in astrocytes. Tissue Specificity: Ubiquitous. High expression in brain followed by testis, muscle, pancreas, heart, ovary, small intestine, placenta, prostate, thymus, kidney, colon, liver, lung, spleen and leukocytes. Expression is reduced in most glioblastomas and all glioblastoma cell lines. Database links: Entrez Gene: 54914 Human SwissProt: Q5VW36 Human Unigene: 136247 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
9号染色体由约1亿4500万个碱基和4%个人类基因组组成，编码近900个基因。考虑到在性别决定中起作用，9p末端的缺失可导致男女性反转，即具有男性X，Y基因型的女性的表型。遗传性出血性毛细血管扩张症以有害的血管缺陷为特征，与编码内皮素蛋白的9号染色体基因ENG相关。家族性自主神经障碍也通过IKBKAP基因与9号染色体相关。值得注意的是，9号染色体包含最大的干扰素家族基因簇。染色体9与22号染色体一起发生易位，导致白血病中常见的BCR-ABL融合蛋白的异常产生。KiaA1797基因产物已暂时指定KIAA1797，有待进一步鉴定。