NHLH1 + NHLH2,螺旋环螺旋蛋白1+2抗体

产品编号HZ-11523R
英文名称NHLH1 + NHLH2
中文名称螺旋环螺旋蛋白1+2抗体
别 名HEN1; HEN2; Nescient helix loop helix 1; HEN1_HUMAN . Nescient helix loop helix 2; NSCL; NSCL1; NSCL2; HEN2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 神经生物学 信号转导 转录调节因子 细胞膜受体 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
NHLH1 + NHLH2,螺旋环螺旋蛋白1+2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量15kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human NHLH1 + NHLH2 (91-133aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
NHLH1 + NHLH2,螺旋环螺旋蛋白1+2抗体PubMedPubMed
产品介绍background:
The helix-loop-helix (HLH) structures are known motifs commonly found in membrane-active and DNA-binding proteins. The helix-loop-helix proteins HEN1 and HEN2 are DNA-binding proteins that may be involved in cell-type determination in the early nervous system. Studies of expression in normal tissues have demonstrated expression of NHLH1/NSCL-1 and NHLH2/NSCL-2, the genes encoding HEN1 and HEN2, in the developing central and peripheral nervous system, specifically in developing neurons.

Function:
NHLH1 and NHLH2 are two basic domain helix-loop-helix (bHLH) proteins expressed predominantly in the developing nervous system and also in some cell lines derived from tumors with neural or neuroendocrine features such as neuroblastoma, PNET, and small cell lung cancer.

Subunit:
Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular Location:
Nucleus

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.

NHLH1 + NHLH2,螺旋环螺旋蛋白1+2抗体Database links:
UniProtKB/Swiss-Prot: Q02575.1 UniProtKB/Swiss-Prot: Q02577.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.