Human Growth Factors & Cytokines
Recombinant Human IFN-beta





 





		Synonyms :
Leukocyte interferon, B cell interferon, Type I interferon



		Description :
Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections.  They also affect cell proliferation and modulate immune responses.  Produced by peripheral blood leukocytes and lymphoblastoid cells, IFNα is an acid stable molecule that signals through IFNα/βR, which is also used by IFNβ.  Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens.  IFNα contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity.  Recombinant human IFNβ is an 20.0 kDa protein containing 166 amino acid residues. Due to glycosylation, IFNβ has an approximate MW of 22.3 kDa based on SDS-PAGE gel and Mass Spectrometry.


*Human IFN-beta(Catalog Number 300-02BC) has replaced Human IFN-beta(Catalog Number 300-02B)




		Catalog #:
300-02BC



		Source :
CHO cells



		Purity :
Greater than 95% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Assay#1:The biological activity of PeproTech's human IFN-β was based on analysis using the WISH cell line with VSV as the challenge virus. The specific activity was determined to be >5 x 10 8 units/mg



Assay#2:Measured by its ability to induce apoptosis in HeLa cells.  The expected ED50 for this effect is 20-30 ng/ml.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN 



		PubMed Link :
IFN-beta


Country of Origin :
USA
















        Size A
5μg
$80 
 


 



        Size B
20μg
$195 
 


 



        Size C
1mg
$3900 
 


 















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.