HSPBAP1,热休克蛋白27相关蛋白1抗体

产品编号HZ-6986R
英文名称HSPBAP1
中文名称热休克蛋白27相关蛋白1抗体
别 名27 KdA heat shock protein-associated protein 1; HBAP1_HUMAN; hspbap; HSPB1-associated protein 1; HSPBAP1; PASS1; Protein associated with small stress protein 1; protein associating with small stress protein.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
HSPBAP1,热休克蛋白27相关蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量54kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human HSPBAP1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
HSPBAP1,热休克蛋白27相关蛋白1抗体PubMedPubMed
产品介绍background:
Heat Shock Protein BAP1 (heat shock 27-kDa-associated protein 1, or HSPBAP1) inhibits the function of heat shock protein 27, which has a neuroprotective effect during experimentally induced epileptic neuropathology. The HSPBAP1 protein, also known as PASS1, contains a jmjC motif, suggesting it is a member of the jumonji family of transcription factors. There is evidence of domain swapping within the jumonji family genes, and the HSPBAP1 gene has been shown to fuse with a novel gene called DIRC3 in hereditary renal cell cancer.

Function:
May play a role in cellular stress response.

Subunit:
Interacts with CRYAB and HSPB1.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Widely expressed.

DISEASE:
Note=A chromosomal aberration involving HSPBAP1 has been found in a family with renal carcinoma. Translocation t(2;3)(q35;q21) with the putative pseudogene DIRC3. Produces an hybrid mRNA encoding a truncated HSPBAP1 lacking the first 36 amino acids.

HSPBAP1,热休克蛋白27相关蛋白1抗体Similarity:
Contains 1 JmjC domain.

Gene ID:
79663

Database links:
Entrez Gene: 79663 Human
Omim: 608263 Human
SwissProt: Q96EW2 Human
Unigene: 29169 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片

Sample:  293T Cell(human) Lysate at 40 ug Lymph node (mouse) Lysate at 40 ug HepG2 Cell(human) Lysate at 40 ug Testis (mouse) Lysate at 40 ug Primary: Anti- HSPBAP1(HZ-6986R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55kD Observed band size: 55 kD