FITC标记的细胞生长调节蛋白CGREF1抗体
产品名称： FITC标记的细胞生长调节蛋白CGREF1抗体
英文名称： Anti-CGREF1/FITC
产品编号： HZ-13882R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CGREF1/FITC Conjugated antibody
FITC标记的细胞生长调节蛋白CGREF1抗体
| 英文名称 | Anti-CGREF1/FITC |
| 中文名称 | FITC标记的细胞生长调节蛋白CGREF1抗体 |
| 别 名 | Cell growth regulator with EF hand domain 1; Cell growth regulator with EF hand domain protein 1; Cell growth regulatory gene 11; Cell growth regulatory gene 11 protein; CGR 11; CGR11; CGRE1_HUMAN; CGREF 1; CGREF1; Hydrophobestin. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞周期蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CGREF1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CGREF1 (cell growth regulator with EF-hand domain 1), also known as CGR11, is a 301 amino acid secreted protein that contains two highly conserved calcium binding EF-hand domains, which are required for mediating cell-cell adhesion. Induced by p53, CGREF1 is able to inhibit cell growth in various cell lines. CGREF1 is encoded by a gene located on human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, Alstrom syndrome, is caused by mutations in the ALMS1 gene, which maps to chromosome 2. Function: Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines. Subunit: Secreted (By similarity). Similarity: Contains 2 EF-hand domains. Database links: Entrez Gene: 10669 Human Omim: 606137 Human SwissProt: Q99674 Human Unigene: 159525 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CGREF1(具有EF-hand结构域1的细胞生长调节剂)又称CGR11，是一种301个氨基酸分泌蛋白，含有两个高度保守的钙结合EF-hand结构域，它们是介导细胞-细胞粘附所必需的。由p53诱导，CGRF1能够抑制各种细胞系中的细胞生长。CGREF1是由位于人类染色体2上的基因编码的，该基因包含1400多个基因，并且包含人类基因组的近8%。小丑鱼鳞病是一种罕见的病态皮肤畸形，与ABCA12基因突变有关，而脂代谢紊乱型谷甾醇血症与ABCG5和ABCG8基因缺陷有关。此外，一种极其罕见的隐性遗传病，阿尔斯特罗姆综合症，是由ALMS1基因突变引起的，该基因定位于染色体2。