NMUR1,G蛋白偶联受体66/神经调节肽U受体1抗体

产品编号HZ-11420R
英文名称NMUR1
中文名称G蛋白偶联受体66/神经调节肽U受体1抗体
别 名FM-3; G protein-coupled receptor 66; G-protein coupled receptor 66; G-protein coupled receptor FM-3; GPR66; Growth hormone secretagogue receptor family Member 3; Neuromedin U Receptor 1; Neuromedin-U receptor 1; NMU-R1; NMUR1; NMUR1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
NMUR1,G蛋白偶联受体66/神经调节肽U受体1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量47kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human NMUR1 (31-80aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
NMUR1,G蛋白偶联受体66/神经调节肽U受体1抗体PubMedPubMed
产品介绍background:
Neuromedin U is a neuropeptide with high activity on smooth muscle. It is widely expressed in gastrointestinal systems and central nervous system (CNS). Peripheral activities of neuromedin U include smooth muscle stimulation, ion transport alterations in the gut and the regulation of local blood flow and adrenocortical function. Neuromedin U receptors 1 and 2 (NMUR1 and NMUR2) are multi-pass membrane proteins that belong to the G-protein coupled receptor 1 family of proteins. Both NMUR1 and NMUR2 act as receptors for the neuromedin U neuropeptide. NMUR1 is detected in peripheral organs, particularly in urogenital and gastrointestinal systems, with highest levels in testis. It’s expression in CNS is low, but the protein has been detected in cerebellum, hippocampus, dorsal root ganglia and spinal cord. NMUR2 is predominantly detected in central nervous system with highest levels detected in medulla oblongata, spinal cord and thalamus. It may also be detected in testis but has low levels of expression in peripheral tissues.

Function:
Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:
Entrez Gene: 10316 Human
Omim: 604153 Human
SwissProt: Q9HB89 Human
Unigene: 471619 Human

NMUR1,G蛋白偶联受体66/神经调节肽U受体1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.