Anti-ApoB/FITC Conjugated抗体
产品名称： Anti-ApoB/FITC Conjugated抗体
英文名称： Anti-ApoB /FITC
产品编号： YB--6333R-FITC
产品价格： null
产品产地： 中国/美国
品牌商标： Ybscience
更新时间： 2023-08-17T10:29:50
使用范围： 科研使用
上海钰博生物科技有限公司
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Anti-ApoB/FITC Conjugated抗体
| 产品编号 | YB-6333R-FITC |
| 英文名称 | Anti-ApoB /FITC |
| 中文名称 | FITC标记的载脂蛋白B抗体 |
| 别 名 | Apo B 100; Apo B; Apo B-100; Apo B-48; ApoB 100; ApoB 48; ApoB; APOB protein; APOB_HUMAN; Apolipoprotein B 100; Apolipoprotein B 48; Apolipoprotein B; Apolipoprotein B-48; FLDB. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, |
| 产品应用 | not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 241/513kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Apolipoprotein B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Involvement in disease: Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 (FHBL1) . A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors. Function: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Subcellular Location: Secreted. Post-translational modifications: Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle. DISEASE: Defects in APOB are a cause of familialhypobetalipoproteinemia type 1 (FHBL1) [MIM:107730]. A disordercharacterized by highly reduced plasma concentrations of lowdensity lipoproteins, and dietary fat malabsorption. Clinicalpresentation may vary from no symptoms to severe gastrointestinaland neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defectiveapolipoprotein B-100 (FDB) [MIM:144010]. FDB is a dominantlyinherited disorder of lipoprotein metabolism leading tohypercholesterolemia and increased proneness to coronary arterydisease (CAD). The plasma cholesterol levels are dramaticallyelevated due to impaired clearance of LDL particles by defectiveAPOB/E receptors. Note=Defects in APOB associated with defects in othergenes (polygenic) can contribute to hypocholesterolemia. Similarity: Contains 1 vitellogenin domain. Database links: Entrez Gene: 338 Human Entrez Gene: 238055 Mouse Omim: 107730 Human SwissProt: P04114 Human SwissProt: E9Q414 Mouse Unigene: 120759 Human Unigene: 221239 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |