Trypsin Inhibitor,胰蛋白酶抑制剂抗体

产品编号HZ-11177R
英文名称Trypsin Inhibitor
中文名称胰蛋白酶抑制剂抗体
别 名Peptidase inhibitor 15; PI-15; 25 kDa trypsin inhibitor; p25TI; Cysteine-rich secretory protein 8; CRISP-8; SugarCrisp; PI15_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
Trypsin Inhibitor,胰蛋白酶抑制剂抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Trypsin Inhibitor
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Trypsin Inhibitor,胰蛋白酶抑制剂抗体PubMedPubMed
产品介绍background:
Cysteine-rich secretory proteins (CRISPs) represent a family of evolutionarily conserved proteins which play a role in the innate immune system and are transcriptionally regulated by androgens in several tissues. CRISP-8 (Cysteine-rich secretory protein 8), also known as PI15 (Peptidase inhibitor 15), P25TI or SugarCrisp, is a 258 amino acid secreted protein that belongs to the CRISP family. Expressed at low levels in thyroid, prostate, salivary and mammary tissue, CRISP-8 functions as a serine protease inhibitor that exhibits weak inhibitory action against Trypsin, a serine protease found in the digestive system. In addition to its role as a protease inhibitor, CRISP-8 is secreted in neuroblastoma and glioblastoma cell lines, suggesting a role for CRISP-8 in tumor formation and metastasis within the central nervous system.

Function:
The soybean trypsin inhibitor was first crystallized by Kunitz in 1945 and is Serine protease inhibitor which displays weak inhibitory activity against trypsin.

Subcellular Location:
Secreted.

Tissue Specificity:
Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and thyroid gland.

Post-translational modifications:
N-glycosylated (Probable).

Similarity:
Belongs to the CRISP family.

Database links:
UniProtKB/Swiss-Prot: O43692.1

Trypsin Inhibitor,胰蛋白酶抑制剂抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.