Rhesus macaque IL-4 R alpha / CD124 Protein
产品名称: Rhesus macaque IL-4 R alpha / CD124 Protein
英文名称: Rhesus macaque IL-4 R alpha / CD124 Protein
产品编号: ILR-C52H8
产品价格: 0
产品产地: USA
品牌商标: ACROBiosystems
更新时间: null
使用范围: null
北京百普赛斯生物科技股份有限公司
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内毒素: Less than 1.0 EU per μg by the LAL method. 纯度: >95% as determined by SDS-PAGE. 活性: N/A 产品背景: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. 产品描述: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.4 kDa. As a result of glycosylation, The protein migrates as 45-50 kDa under reducing (R) condition and 90-116 kDa under non-reducing (NR) condition on SDS-PAGE gel.SDS-PAGE