PTGS1 polyclonal antibody
产品名称： PTGS1 polyclonal antibody
英文名称： PTGS1 polyclonal antibody
产品编号： PAB7967
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PTGS1.
- Immunogen:
- A synthetic peptide corresponding to amino acids at N-terminus of human PTGS1.
- Sequence:
- QGICVRFGLDRYQC
- Host:
- Rabbit
- Theoretical MW (kDa):
- 68.5
- Reactivity:
- Human, Mouse, Rat
- Form:
- Lyophilized
- Purification:
- Affinity purification
- Storage Buffer:
- Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
- Storage Instruction:
- Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.
Langenbach R, Morham SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC, Mahler JF, Lee CA, Goulding EH, Kluckman KD, Kim HS, Smithies O.Cell. 1995 Nov 3;83(3):483-92.
- 2.
- Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme.
Yokoyama C, Tanabe T.Biochem Biophys Res Commun. 1989 Dec 15;165(2):888-94.
- Entrez GeneID:
- 5742
- Gene Name:
- PTGS1
- Gene Alias:
- COX1,COX3,PCOX1,PGG/HS,PGHS-1,PGHS1,PHS1,PTGHS
- Gene Description:
- prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
- Omim ID:
- 176805
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq
- Other Designations:
- OTTHUMP00000022052,OTTHUMP00000022053,prostaglandin G/H synthase and cyclooxygenase,prostaglandin-endoperoxide synthase 1
- Gene Pathway
- Related Disease