Anti-Apaf1 Interacting Protein抗体
产品名称： Anti-Apaf1 Interacting Protein抗体
英文名称： Apaf1 Interacting Protein
产品编号： YB--6792R
产品价格： null
产品产地： 中国/美国
品牌商标： Ybscience
更新时间： 2023-08-17T10:29:50
使用范围： 科研使用
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Anti-Apaf1 Interacting Protein抗体
| 产品编号 | YB-6792R |
| 英文名称 | Apaf1 Interacting Protein |
| 中文名称 | 凋亡蛋白活性因子1相互作用蛋白抗体 |
| 别 名 | MTNB_HUMAN; Apaf1 Interacting Protein; APIP2; CG129; CGI 29; MMRP19; MTRu 1 P dehydratase; Probable methylthioribulose 1 phosphate dehydratase. |
| 规格价格 | 100ul/1580元 购买 200ul/2480元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 信号转导 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human APIP:151-242/242 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The mammalian homologues of the key cell death gene CED 4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase 9 (Apaf3), which leads to caspase 9 activation. Activated caspase 9 in turn cleaves and activates caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. A new Apaf1 Interacting Protein (APIP) also known as CG129 and MMRP19, has been identified as a negative regulator of ischemic injury. APIP competes with Caspase 9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney. Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Has an anti-apoptotic function and prevents muscle ischemic damage. Inhibits the cytochrome c-dependent and APAF1-mediated cell death. Subunit: Interacts with APAF1. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitously expressed with high expression in skeletal muscle, heart and kidney. Similarity: Belongs to the aldolase class II family. MtnB subfamily. SWISS: Q96GX9 Gene ID: 51074 Database links: Entrez Gene: 508345 Cow Entrez Gene: 475943 Dog Entrez Gene: 32334 Fruit fly (Drosophila melanogaster) Entrez Gene: 100732536 Guinea pig Entrez Gene: 51074 Human Entrez Gene: 56369 Mouse Entrez Gene: 100525733 Pig Entrez Gene: 295961 Rat Entrez Gene: 447941 Zebrafish Omim: 612491 Human SwissProt: Q0VCJ2 Cow SwissProt: Q9VY93 Fruit fly (Drosophila melanogaster) SwissProt: Q96GX9 Human SwissProt: Q8BP46 Mouse SwissProt: Q9WVQ5 Mouse SwissProt: Q66I75 Zebrafish Unigene: 5343 Fruit fly (Drosophila melanogaster) Unigene: 447794 Human Unigene: 24772 Mouse Unigene: 15452 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |