Cyclooxygenase 1,前列腺素氧化环化酶1抗体

产品编号HZ-0582R
英文名称Cyclooxygenase 1
中文名称前列腺素氧化环化酶1抗体
别 名Cyclooxygenase-1; Cyclooxygenase 1; COX-1; COX 1; COX1; Cyclooxygenase1; Prostaglandin-endoperoxide synthase-1; prostaglandin-endoperoxide synthase 1; PTGS-1; Prostaglandin G/H synthase 1 precursor; prostaglandin G/H synthase 1 isoform 1 precursor; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; PGH1_HUMAN; PTGS1; Prostaglandin G/H synthase 1 precursor.
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 免疫学 信号转导 合成与降解
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
Cyclooxygenase 1,前列腺素氧化环化酶1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量63kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Cyclooxygenase 1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Cyclooxygenase 1,前列腺素氧化环化酶1抗体PubMedPubMed
产品介绍background:
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012].

Function:
May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.

Subunit:
Homodimer.

Subcellular Location:
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.

Similarity:
Belongs to the prostaglandin G/H synthase family.
Contains 1 EGF-like domain.

Gene ID:
5742

Cyclooxygenase 1,前列腺素氧化环化酶1抗体Database links:
Entrez Gene: 5742 Human
Entrez Gene: 19224 Mouse
Entrez Gene: 24693 Rat
Omim: 176805 Human
SwissProt: P23219 Human
SwissProt: P22437 Mouse
SwissProt: Q63921 Rat
Unigene: 201978 Human
Unigene: 275434 Mouse
Unigene: 44404 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成与降解（Synthesis and Degradation）
COX1 前列腺素氧化环化酶-是前列腺素合成的关键酶之一，为诱导性酶，他参与细胞对生长因子、肿瘤促进因子和细胞因子的反应，这些因子均能诱导COX1表达，它也参与前列腺素的合成。