FITC标记的STRN4蛋白抗体
产品名称： FITC标记的STRN4蛋白抗体
英文名称： Anti-Striatin 4/FITC
产品编号： HZ-12136R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Striatin 4/FITC Conjugated antibody
FITC标记的STRN4蛋白抗体
| 英文名称 | Anti-Striatin 4/FITC |
| 中文名称 | FITC标记的STRN4蛋白抗体 |
| 别 名 | Striatin-4; STRN4; STRN4_HUMAN; ZIN; Zinedin. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 激酶和磷酸酶 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 80kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Striatin 4/zinedin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Striatin, SG2NA, and zinedin, the three mammalian members of the striatin family, are multimodular, WD-repeat and calmodulin-binding proteins. Zinedin and SG2NA share with striatin identical protein-protein interaction domains and the same overall domain structure. All three proteins are both cytosolic and membrane-bound and bind calmodulin in the presence of calcium. Striatin is a neuronal, intracellular protein strictly expressed in the somatodendritic compartment, including spines, subsets of neurons, and is considered as a marker of neuronal polarity. Downregulation of striatin, which is expressed in a few subsets of neurons, impairs the growth of dendrites as well as rat locomotor activity. Zinedin is mainly expressed in the central nervous system, whereas SG2NA is mainly expressed in the brain and muscle. Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. Subcellular Location: Cytoplasm. Membrane. Similarity: Belongs to the WD repeat striatin family. Contains 7 WD repeats. Database links: Entrez Gene: 29888 Human Entrez Gene: 97387 Mouse Entrez Gene: 308392 Rat Omim: 614767 Human SwissProt: Q9NRL3 Human SwissProt: P58404 Mouse Unigene: 631590 Human Unigene: 21612 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
纹状体蛋白、SG2NA和锌离子是纹状体蛋白家族的三个哺乳动物成员，是多模块、WD重复和钙调素结合蛋白。Zinedin和SG2NA与纹状体相同的蛋白质-蛋白质相互作用结构域和相同的整体结构域共享。所有这三种蛋白质都是胞浆和膜结合，并结合钙调素在钙的存在。纹状体蛋白是一种神经元胞内蛋白，严格表达于躯体树突室，包括脊椎、神经元亚群，被认为是神经元极性的标志物。在少数神经元亚群中表达的纹状体下调会损害树突的生长以及大鼠的运动活动。ZNEDIN主要表达于中枢神经系统，而SG2NA主要表达于脑和肌肉。