TALLA-1,T细胞急性淋巴母细胞白血病相关抗原1抗体

产品编号HZ-9416R
英文名称TALLA-1
中文名称T细胞急性淋巴母细胞白血病相关抗原1抗体
别 名CD231 antigen; Cell surface glycoprotein A15; Membrane component X chromosome surface marker 1; T cell acute lymphoblastic leukemia associated antigen 1; TALLA 1; TALLA1; Tetraspanin 7; Tetraspanin-7; Transmembrane 4 superfamily member 2; Tspan 7; TSN7_HUMAN; Tspan-7; TALLA-1.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 信号转导 细胞表面分子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
TALLA-1,T细胞急性淋巴母细胞白血病相关抗原1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量28kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Tetraspanin-7
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
TALLA-1,T细胞急性淋巴母细胞白血病相关抗原1抗体PubMedPubMed
产品介绍background:
Tetraspanins are a group of hydrophobic membrane proteins that interact with a wide variety of proteins including intracellular signaling molecules, integrins and membrane receptors. TSPAN7 (tetraspanin 7), also known as MXS1 (membrane component chromosome X surface marker 1) or TM4SF2 (transmembrane 4 superfamily member 2), is a 249 amino acid multi-pass membrane protein belonging to the tetraspanin (TM4SF) family of transmembrane proteins. TSPAN7 is believed to play a role in cell motility and cell proliferation. The gene that encodes TSPAN7 maps to human chromosome X and defects in this gene are a cause of mental retardation X-linked type 58 (MRX58), which is characterized by dramatically below average general intellectual functioning.

Function:
May be involved in cell proliferation and cell motility.

Subunit:
Interacts with herpes simplex virus 1 (HHV-1) UL35.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.

DISEASE:
Defects in TSPAN7 are the cause of mental retardation X-linked type 58 (MRX58) [MIM:300210]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.

TALLA-1,T细胞急性淋巴母细胞白血病相关抗原1抗体Similarity:
Belongs to the tetraspanin (TM4SF) family.

Database links:
UniProtKB/Swiss-Prot: P41732.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.