FEN1 polyclonal antibody (A01)
产品名称： FEN1 polyclonal antibody (A01)
英文名称： FEN1 polyclonal antibody (A01)
产品编号： H00002237-A01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a partial recombinant FEN1.
- Immunogen:
- FEN1 (NP_004102, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag.
- Sequence:
- MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQ
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- 50 % glycerol
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (38.21 KDa) .
- MSDS:
Download
- Applications
- Western Blot (Cell lysate)
- FEN1 polyclonal antibody (A01), Lot # 051011JC01 Western Blot analysis of FEN1 expression in Hela NE ( Cat # L013V3 ).
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Entrez GeneID:
- 2237
- GeneBank Accession#:
- NM_004111
- Protein Accession#:
- NP_004102
- Gene Name:
- FEN1
- Gene Alias:
- FEN-1,MF1,RAD2
- Gene Description:
- flap structure-specific endonuclease 1
- Omim ID:
- 600393
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq
- Other Designations:
- DNase IV,maturation factor-1
- Related Disease
- Breast cancer
- Breast Neoplasms
- Coronary Artery Disease
- DNA Damage
- Genetic Predisposition to Disease
- Graft vs Host Disease
- Head and Neck Neoplasms
- Huntington Disease
- Huntington disease
- Lung Neoplasms
- Lupus Erythematosus, Systemic
- Multiple Sclerosis
- Neoplasm Recurrence, Local
- Neoplasms, Second Primary