Background:  Kruppel-like factors (KLFs) comprise a family of evolutionarily conserved zinc finger-containing transcription factors with diverse regulatory functions in cell growth, proliferation, differentiation and embryogenesis. Individual members of the Sp1-like/KLF family can function either as activators or repressors, depending on which promoter they bind and the co-regulators with which they interact. KLF6, also designated Zf9 or CPBP (core promoter-binding protein), and KLF3 are Kruppel-like zinc finger containing transcription factors. KLF6 is rapidly induced during hepatic stellate cell activation and transactivates a reporter gene driven by the Collagen I promoter, suggesting KLF6 plays a role in the response to tissue injury. KLF3 may play a role in hematopoiesis. The human homolog is a transcription factor involved in haematopoietic differentiation. It binds to the CACCC box.

Description: Rabbit polyclonal to KLF3

Immunogen: KLH conjugated synthetic peptide derived from KLF3

Specificity:  ·Reacts with Human, Mouse and Rat.      

·Isotype: IgG

Application:  ·Western blotting: 1/500-1000. Predicted Mol wt: 35 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;

·Immunocytochemistry: 1/200-500;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.