FITC标记的半胱胺酸蛋白酶蛋白-12抗体
产品名称： FITC标记的半胱胺酸蛋白酶蛋白-12抗体
英文名称： Anti-Caspase-12/FITC
产品编号： HZ-23014R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Caspase-12/FITC Conjugated antibody
FITC标记的半胱胺酸蛋白酶蛋白-12抗体
| 英文名称 | Anti-Caspase-12/FITC |
| 中文名称 | FITC标记的半胱胺酸蛋白酶蛋白-12抗体 |
| 别 名 | Caspase-12; UNQ9415; Apoptosis related cysteine protease; CASP 12; casp12; CASP12P1; Caspase 12 pseudogene 1; CASP-12; casp12; caspase 12 (gene/pseudogene); Caspase12; CASPC_HUMAN; OTTHUMP00000207026; OTTHUMP00000207028; OTTHUMP00000207031; OTTHUMP00000207032; OTTHUMP00000219058; UNQ9415. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Caspase-12 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011] Function: Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. Tissue Specificity: Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. Similarity : Belongs to the peptidase C14A family. Similarity: Belongs to the peptidase C14A family. Contains 1 CARD domain. Database links: Entrez Gene: 100506742 Human SwissProt: Q6UXS9 Human Unigene: 476989 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ASPASE-12是caspase家族成员，是存在于内质网上的促凋亡因子，内质网应激早期可通过GRP（glucose-regulated protein，GRP）的表达增多来保护细胞；CASPASE-12是内质网细胞关键介导因子，caspase-12还是caspase-1的抑制剂 |
半胱氨酸蛋白酶是半胱氨酸蛋白酶，能裂解其底物分子上的C端天冬氨酸残基。该基因与处理炎性细胞因子的半胱氨酸蛋白酶ICE亚家族成员高度相关。在啮齿动物中，该基因的同源物对内质网应激反应介导细胞凋亡。然而，在人类中，这个基因包含一个多态性，表明是否存在过早的终止密码子。大多数人类个体具有过早的终止密码子，并产生截短的非功能性蛋白质。该密码子主要发生在非洲血统的个体中，携带者具有内毒素低反应性和对严重脓毒症的易感性增加。几个替代剪接转录变体已经注意到这个基因。[ RefSeq，FEB 2011 ]提供