SHFM3,SHFM3蛋白抗体

产品编号HZ-8390R
英文名称SHFM3
中文名称SHFM3蛋白抗体
别 名DAC; Dactylin; F box and WD 40 domain containing protein 4; F box and WD 40 domain protein 4; F box and WD repeat domain containing 4; F box/WD repeat containing protein 4; F box/WD repeat protein 4; F-box and WD-40 domain-containing protein 4; F-box/WD repeat-containing protein 4; FBW 4; FBW4; FBWD 4; FBWD4; FBXW 4; FBXW4; FBXW4_HUMAN; SHFM 3; SHSF 3; SHSF3; Split hand/foot malformation (ectrodactyly) type.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
SHFM3,SHFM3蛋白抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量46kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SHFM3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
SHFM3,SHFM3蛋白抗体PubMedPubMed
产品介绍background:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.
Involvement in disease:Defects in FBXW4 are a cause of split-hand/foot malformation type 3 (SHFM3) . SHFM3 is an autosomal dominant disorder characterized by hypoplasia/aplasia of the central digits with fusion of the remaining digits.

Function:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.

Subunit:
Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).

Subcellular Location:
Expressed in brain, kidney, lung and liver.

Tissue Specificity:
Expressed in brain, kidney, lung and liver.

SHFM3,SHFM3蛋白抗体DISEASE:
Defects in FBXW4 are a cause of split-hand/foot malformation type 3 (SHFM3) [MIM:246560]. SHFM3 is an autosomal dominant disorder characterized by hypoplasia/aplasia of the central digits with fusion of the remaining digits.

Similarity:
Contains 1 F-box domain.
Contains 4 WD repeats.

Database links:
UniProtKB/Swiss-Prot: P57775.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.