ARNT monoclonal antibody (M02), clone 1F12
产品名称: ARNT monoclonal antibody (M02), clone 1F12
英文名称: ARNT monoclonal antibody (M02), clone 1F12
产品编号: H00000405-M02
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant ARNT.
- Immunogen:
- ARNT (AAH60838, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYIT
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG1 Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.73 KDa) .
- MSDS:
- Download
- Applications
- Western Blot (Recombinant protein)
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged ARNT is approximately 0.3ng/ml as a capture antibody.
- Protocol Download
- Application Image
- Western Blot (Recombinant protein)
- Sandwich ELISA (Recombinant protein)
- enlarge
- ELISA
- Entrez GeneID:
- 405
- GeneBank Accession#:
- BC060838
- Protein Accession#:
- AAH60838
- Gene Name:
- ARNT
- Gene Alias:
- HIF-1beta,HIF1B,HIF1BETA,TANGO,bHLHe2
- Gene Description:
- aryl hydrocarbon receptor nuclear translocator
- Omim ID:
- 126110
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000032943,dioxin receptor, nuclear translocator,hypoxia-inducible factor 1, beta subunit
- Gene Pathway
- Related Disease
- Abortion, Habitual
- Adenocarcinoma
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Diabetes Mellitus, Type 2
- Edema
- Endometriosis
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Infertility, Male
- Lung Neoplasms
- Parkinson Disease
- Parkinson disease
- Prediabetic State
- Prostate cancer
- Pulmonary Disease, Chronic Obstructive
- Thyroid Neoplasms
- Urinary Bladder Neoplasms